Communication by helix
نویسندگان
چکیده
منابع مشابه
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication.
Sequence motifs are responsible for ensuring the proper assembly of transmembrane (TM) helices in the lipid bilayer. To understand the mechanism by which the affinity of a common TM-TM interactive motif is controlled at the sequence level, we compared two well characterized GXXXG motif-containing homodimers, those formed by human erythrocyte protein glycophorin A (GpA, high-affinity dimer) and ...
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DNA recognition by proteins with the helix-turn-helix motif.
INTRODUCTION......... . ...... ................. .. ................. . .... . . ................. ......... 933 NOTIONS ABOUT RECOGNITION..... ................ . . .............. . . ..... . ......... . . ..... 934 THE HTH MOTIF... ..... ....... ................. .. . ................ .... . . .... ........... . .. . ..... .. 936 STRUCTURES.... . . . ..... .. ......... . . ................ ......
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The way helix-turn-helix proteins recognize DNA is analysed by comparing their sequences, structures, and binding specificities. Individual recognition helices in these proteins bind to four DNA base pairs with the same geometry. However, pairs of recognition helices in the protein dimers can have different separations and orientations. These differences are used for discriminating between DNAs...
متن کاملID helix-loop-helix proteins
The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...
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ژورنال
عنوان ژورنال: Nature
سال: 1994
ISSN: 0028-0836,1476-4687
DOI: 10.1038/370392a0